Etymed
autoimmunity
Definition
The immune system's response to self-antigens, resulting in autoimmune diseases where the body's immune system attacks its own healthy tissues.
Clinical context
A 35-year-old woman presents with joint pain, fatigue, and a malar rash. Laboratory tests reveal positive antinuclear antibodies and elevated inflammatory markers. She is diagnosed with systemic lupus erythematosus, a classic example of autoimmunity where the immune system targets multiple organ systems. Her condition requires long-term immunosuppressive therapy to control the autoimmune response.
Mnemonic
AUTO = Attack Our Tissues, IMMUNITY = Immune System Overreaction