Etymed
immunodeficiency
Definition
A condition in which the immune system is deficient or impaired, leading to increased susceptibility to infections
Clinical context
A 3-year-old child presents with recurrent respiratory infections, including pneumonia caused by opportunistic pathogens. Laboratory studies reveal low levels of immunoglobulins and impaired T-cell function. The child's family history reveals multiple relatives with similar infections and early mortality. This patient most likely has a primary immunodeficiency disorder.
Mnemonic
IMMUNE deficiency = Infections, Malnutrition, Metabolism, Inflammation, Neoplasms, Endocrine disorders