Etymed
plasmacytoma
Definition
A malignant tumor composed of plasma cells
Clinical context
A 65-year-old man presents with bone pain and pathological fractures of the vertebrae. Imaging reveals multiple lytic lesions in the spine and skull. Laboratory studies show elevated serum protein levels with monoclonal IgG kappa light chains. Bone marrow biopsy demonstrates sheets of atypical plasma cells. What is the most likely diagnosis? A 50-year-old woman presents with fatigue and weight loss. Physical examination reveals multiple enlarged lymph nodes. Biopsy of a cervical lymph node shows malignant plasma cells infiltrating the tissue. What is the primary diagnosis?
Mnemonic
PLASMA = Plasmacytoma, Lymphoma, Multiple Myeloma, Acute leukemia, Sarcoidosis, Angioimmunoblastic lymphoma