Etymed

polycystic kidney disease

poly- cyst/o -ic kidney disease

Definition

A genetic disorder characterized by the growth of numerous cysts in the kidneys, leading to kidney enlargement and potential kidney failure

Clinical context

A 35-year-old woman presents with a 6-month history of flank pain and hematuria. She has a family history of kidney disease, with her father and uncle both diagnosed with polycystic kidney disease. Imaging reveals multiple bilateral renal cysts and enlarged kidneys. Her blood pressure is elevated at 160/95 mmHg. The patient's condition is likely caused by mutations in the PKD1 gene, which leads to progressive cyst formation and kidney dysfunction.

Mnemonic

POLY cysts cause PROGRESSIVE kidney failure - 'P' for Polycystic, 'O' for Overgrowth, 'L' for Large cysts, 'Y' for Yearly deterioration, 'C' for Cysts, 'K' for Kidney, 'D' for Deterioration

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