Etymed
sertoli cell tumor
Definition
A tumor arising from Sertoli cells in the testes, characterized by abnormal growth of these supportive cells that normally nourish developing sperm cells
Clinical context
A 35-year-old man presents with gradual onset of breast enlargement and gynecomastia. Physical examination reveals firm, painless testicular masses. Laboratory studies show elevated estrogen levels and normal testosterone levels. Imaging demonstrates bilateral testicular masses with characteristic 'pseudoglandular' appearance on ultrasound.
Mnemonic
Sertoli cells produce 'SERTOLI' - Sertoli cells are the 'S' cells that make 'TOLI' (testosterone) - but in tumors, they make 'SERTOLI' with abnormal 'SERTOLI' growth patterns
These morphemes also unlock…
- Sertoli — named after Enrico Sertoli, Italian physiologist
- cell — small room; basic unit
- tumor — swelling; mass